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Impairment of autonomic function, of which orthostatic hypotension is the most serious feature, may occur as part of the more common acute or chronic peripheral neuropathies (eg, diabetic, alcoholic-nutritional, amyloid, Guillain-Barre, heavy metal toxic, and porphyric) Disease of the peripheral nervous system may affect the circulation in two ways: the nerves from baroreceptors may be affected, interrupting normal homeostatic re exes on the afferent side, or postganglionic efferent sympathetic bers may be involved in the spinal nerves The severity of the autonomic failure need not parallel the degree of motor weakness An additional feature of the acute dysautonomias is a tendency to develop hypona-

protected void Page_Load(object sender, EventArgs e)

tremia, presumably as a result of dysfunction of afferent bers from aortic arch volume receptors, which elicits a release of vasopressin These same stretch baroreceptors are implicated in the intermittent hypertension that sometimes complicates these acute neuropathies Of particular importance is the autonomic disorder that accompanies diabetic neuropathy It presents as impotence, constipation, or diarrhea (especially at night), hypotonia of the bladder, gastroparesis, and orthostatic hypotension, in some combination There are invariably signs of a sensory polyneuropathy, consisting of a distal loss of vibratory and thermal-pain sensation and reduced or lost ankle re exes; but again, the severity of affection of the two systems of nerve bers may not be parallel The pupils are often small and the amplitude of constriction to light is reduced (ArgyllRobertson pupils); this has been attributed to involvement of the ciliary ganglia The pathologic basis of the other features has been dif cult to assess because of the frequency of artifact in the sympathetic ganglia in autopsy material Duchen and coworkers attributed the autonomic disorder to vacuolization of sympathetic ganglionic neurons, cell necrosis and in ammation, loss of myelinated bers in the vagi and white rami communicantes, and loss of lateral horn cells in the spinal cord They believe the latter changes to be secondary Another polyneuropathy with unusually prominent dysautonomia is that due to amyloidosis Extensive loss of pain and thermal sensation is usually present; other forms of sensation may also be reduced to a lesser degree Motor function is much less altered Sympathetic function is more affected than parasympathetic Iridoplegia (pupillary paralysis) and disturbances of other smooth muscle and glandular functions are variable Diabetic and amyloid polyneuropathy are further described in Chap 46 Both the primary and secondary types of orthostatic hypotension are also discussed in connection with syncope in Chap 18

is Generating bestfit by solving the normal equations widely usedand certainlyadequate a It for many curve-fittingapplications engineering in and science must be mentioned, howcan to ever,tlrat the normal equations be ill-conditionedandhencesensitive roundoff errors Two more advanced methods,QRfactorization andsingular valuedecomposition, are more robustin this regardAlthough the descriptionof thesemethodsis beyondthe scope of this text, we mention them herebecause they can be implementedwith MATLAB FurtherQR factorizationis automaticallyusedin two simple ways within MATLAB First, for caseswhere you want to fit a polynomial, the built-in polyf it function automatically usesQR factorizationto obtain its results problemcan be directly solvedwith the backSecond, generallinear least-squares the Recallthat the general modelis formulated Eq (148) as slashoperator 1 y y: l Z l { a l ( 1 4I l )

The name of the method is actually Page_Load, and the event that assigns the name Page_Load is part of C# and ASPNET assignment In other words, the event name is not Page_Load but something else In this case, it s a built-in OnLoad event assigned the value that Page_Load associated with the page object Because the name Page_Load sounds like an event, often developers just assume it s an event, but it s not It could have been named anything Hip_Hop, if the designers so desired

dominant pattern of inheritance (Robinson and colleagues) Stabbing pains in the feet were increased by bending, crouching, and kneeling There was no sweat response to intradermal injection of 1% ACh and no autonomic bers were found in punch biopsies of the skin Fabry disease was excluded

In Section104,we usedleft divisionwith thebackslash operator solvesystems linearalto of gebraicequations wherethe numberof equations equalsthe numberof unknowns(n : n) Ieastsquares, numberof equations greaterthan For Eq ( 148)as derivedfiom general the is When the number of unknowns (n> m)Such systemsare said to be overdetermined MATLAB senses you want to solvesuchsystems with left division,it automatically uses that how this is done to QR factorization obtainthe solutionThe following exampleillustrates E X A M P L1 4 4 E l m p l e m e n t i n g o l y n o m i o R e g r e s s i o w i t h p o , y i j t o n d L e f tD i v i s i o n P l n Problem Stotemeni RepeatExample 143,but use the builrin polyf ir functionand left division to calculatethe coefficients Solution As in Example 143,the datacan be enteredand usedto createthe lZl matrix as in

The main shortcut for generating an event associated with a web control has been to double-click a web control in the Design mode and to use the default function name that appears in the C# code For example, if you double-click a TextBox control, you can expect to see the C# method beginning